Buff lab notebook `Mouse book factor IX', containing details of experiments leading to development of a monoclonal antibody to factor IX (the first monoclonal antibody raised against a plasma coagulation factor)

Labelled “Mouse Book, Factor IX”, this laboratory notebook details experiments by Edward Tuddenham, Frances Rotblat and Donogh O’Brien at the Clinical Research Centre, Northwick Park, which is to the north of London. This work led to the development of a monoclonal antibody to Factor IX. Monoclonal antibodies are identical antibodies cloned from a single cell. Factor IX is one of the factors involved in blood clotting. Its absence causes a type of haemophilia, treatable using Factor IX from human blood plasma. It is shown here with an open laboratory notebook on purification of Factor VIII (1994-1204).

The work of Professor Tuddenham led to the development by the Genentech corporation of Factor VIII which was produced by bacteria rather than humans.