Poster for the film 'Osmosis Jones', 2001.

'Osmosis Jones' is a 2001 American live-action/animated action comedy with animated scenes directed by Tom Sito and Piet Kroon and live action scenes directed by the Farrelly brothers. The film centers on Frank Detorre, a slovenly zookeeper; the live-action scenes are set outside Frank's body, while the animated scenes are set inside his body, which is portrayed as a city inhabited by anthropomorphic blood cells and microorganisms. White blood cell cop Osmosis "Ozzy" Jones and cold pill Drix must prevent deadly virus Thrax from killing Frank within forty-eight hours.