Sankeys Soap was a nightclub in Manchester's Ancoats district. Andy Spiro and Rupert Campell opened the club and live music venue in 1994 in the basement of the Beehive Mill, a former soap factory. Although it came close to collapsing within the first six month, the business managed to thrive until financial trouble forced it to close in 1998.

In 2000 business partners David Vincent and Sacha Lord-Marchionne re-opened the business, solving some of the previous issues and increasing its popularity. Despite this, the club was again closed in 2006, but its revival was soon announced with David Vincent inviting Andy Spiro to become involved again as a partner. The club was renamed Sankeys and went through a major refit. The club included a beach made of sand imported from the Bahamas. The club played mainly techno and house music, but also had occasional nights from outside promoters.

The success of Sankeys led to the announcement of plans to open seven more clubs around the world, including in Ibiza, Tokyo and New York. Sankeys Manchester closed again between May and December of 2013, re-opening in January 2014.

The sale of the Beehive Mill to developers creating flats led to the final closure of Sankeys Manchester venue in January 2017.