William Duckworth founded a manufacturing chemists company in Corporation Street, Manchester in 1885. Duckworth entered into partnership with Samuel Kirtlan. The original company name was Duckworth and Kirtlan. The partnership was dissolved in 1887 and the company continued as Duckworth & Co. The company moved to purpose built premises known as Old Trafford Essence Distillary on Chester Road in 1895 for the manufacture of concentrated soluble essences, essential oils and colours supplied to the aerated water trade (i.e. local 'pop' men). Duckworths were leaders in the field, supplying flavours and essences around the world and developing products tailored to specific markets. The ledgers, product labels and label printing blocks represent the trade and products of this company.

Duckworth & Co was acquired by Cargill Flavor Systems (UK) Ltd in 2003. The company vacated the Chester Road premises in 2006.