The Greater Manchester Chamber of Commerce was established in April 1794 as the Manchester Commercial Society at Spencer's Tavern, St Ann's Square, Manchester. In 1810 it became known as the Manchester Chamber of Commerce, a name it held until 1970, when it became the Manchester Chamber of Commerce and Industry. Later it became the Greater Manchester Chamber of Commerce. As of 2024 it was the largest accredited Chamber of Commerce in the UK with over 4000 members. The Chamber enables its members to network and represents the interests of businesses locally.