Chesapeake & Ohio Railway 1869 - 1972
- Cleveland, Cuyahoga county, Ohio, United States
Formed in 1869 in Virginia from many smaller railroads. It served the states of the District of Columbia, Illinois, Indiana, Kentucky, Michigan, New York, Ohio, Virginia, West Virginia, and Wisconsin. in 1972 it became part of the Chessie System, along with the Baltimore and Ohio and Western Maryland Railway.