In 1948, 3M produced surgical drapes which marked the beginning of the company's pursuit into healthcare. In 1960, the company produced their Micropore Surgical Tape, which was the first hypoallergenic tape and became key to the success of 3M's health care business.

This health care branch of the business has 6 separate focuses. These include medical solutions, oral care, health information systems, food safety, biopharmaceuticals, and medical device components.