1839 - June 23, Julius Wilhelm Braun purchases the Rosen-Apotheke, a pharmacy in Melsungen, Germany and expands it as a mail-order business for local herbs;

1864 - Bernhard Braun, eldest son of J W Braun, takes over the pharmacy and begins producing pharmaceutical products like migraine sticks and plasters;

1867 - Bernhard Braun registers the company name in the commercial register as B. Braun; company is divided into Department A (pharmacy) and Department B (pharmaceutical products)