Inventor of the wire-cable suspension bridge and the multi-tubular steam-engine boiler.

Seguin designed and built locomotives for the St. Etienne-Lyon Railway. He had visited the Stockton & Darlington Railway shortly after it opened in 1825 and purchased two engines from Robert Stephenson & Company, which had problems adapting to the French line. Seguin therefore presented his own engines to the St. Etienne-Lyon Railway. See also 1925-118, Model of Seguin's locomotive.