DGP Pathoseal 95 biohazard bag numbered 18335519 and labelled ATTAC Day 1 containing 3 BD Vacutainer 10ml tube with green screw cap, BD Vacutainer Safety-Lok blood collection set, expiry date 2021-12-31 and lot number 19M27T1, pink rubber tourniquet, round Steroplast adhesive dressing, BD Vacutainer 4ml tube with red screw cap, Clinell alcohol skin wipe, ball of cotton wool, BD Vacutainer One-Use Holder, and rectangle of absorbent material equipment for blood testing of participants in the INSTINCT study (who are contacts of someone who has tested positive for COVID-19 on day 1 post symptoms), 2020

In the INSTINCT study, household contacts living with people with a recent COVID-19 infection were enrolled at home by research nurses (day 0) and visited again on days 7, 14 and 27. The green top tubes are used to isolate plasma and immune cells. These cells are tested further using flow cytometry to understand which parts of a person’s immune system is responding to COVID-19. The red topped tube is for collection of serum. This serum is initially used to test for COVID-19 antibodies and cytokine responses to infection.

Combined nose and throat swabs for reverse transcriptase (RT)-PCR testing. Nasal and stool samples were also taken to study immune responses and whether the virus is present in faeces. Samples over time helps identify virus changes and mutations and identify if there are any links between specific strains of virus and disease outcome. Participants also tracked their symptoms over 28 days in a diary.

If eligible to take participate in the study, people were taken through what the study was and what would happen to their data and samples. If they agreed to take part, they each signed a consent form and parents or guardian gave permission for over 5 year olds but under 18s to take part. The study looked at what proportion of infections that are symptom-free, what are the risk factors of COVID-19 transmission within household and whether early immune responses could predict if a recently-exposed person (contact) will have a symptom-free infection or instead develop symptomatic or severe illness.

DGP Pathoseal 95 biohazard bag numbered 18463607 containing a purple topped BD Vacutainer EDTA (Ethylenediamine tetraacetic acid) Blood Collection Tube which prevents the blood sample from clotting, for blood testing of participants in the Ithe Integrated Network for Surveillance, Trials and Investigation of COVID-19 Transmission (INSTINCT) study, 2020

In the INSTINCT study, household contacts living with people with a recent COVID-19 infection were enrolled at home by research nurses (day 0) and visited again on days 7, 14 and 27. Blood samples are taken for the study team to investigate. The purple topped tube contains an anti-coagulant to stop samples clotting on their way to the lab. A full blood count is studied as is haemoglobin A1C levels, which is an indicator of diabetes. The team were looking to see if the condition influences people’s immune response to COVID-19.

Combined nose and throat swabs for reverse transcriptase (RT)-PCR testing were also taken. Nasal and stool samples were also collecting to study immune responses and whether the virus is present in faeces. Sampling over time helps identify virus changes and mutations and identify if there are any links between specific strains of virus and disease outcome. Participants also tracked their symptoms over 28 days in a diary.

If eligible to take participate in the study, people were taken through what the study was and what would happen to their data and samples. If they agreed to take part, they each signed a consent form and parents or guardian gave permission for over 5 year olds but under 18s to take part. The study looked at what proportion of infections that are symptom-free, what are the risk factors of COVID-19 transmission within household and whether early immune responses could predict if a recently-exposed person (contact) will have a symptom-free infection or instead develop symptomatic or severe illness.

DGP Pathoseal 95 biohazard bag numbered 18335316 containing sterile MANTACC swab and MANTACC tube with red screw cap containing UTM transport medium, expiry date 2022/03/10, lot number 2020030058, made by Miraclean Technology Co., Ltd, and rectangle of absorbent material, used to take nasal and throat samples from people enrolled on the Integrated Network for Surveillance, Trials and Investigation of COVID-19 Transmission (INSTINCT) study, 2020

In the INSTINCT study, household contacts living with people with a recent COVID-19 infection were enrolled at home by research nurses (day 0) and visited again on days 7, 14 and 27. Nose and throat samples were taken to be tested for COVID-19 and people also carried out an addition test on day 4. The liquid in the tube is known as VTM (viral transport media) to ensure the safe transfer of a sample to the lab for PCR testing. Blood, stool and nasal samples are also taken. Sampling over time helps identify virus changes and mutations and identify if there are any links between specific strains of virus and disease outcome. Participants also tracked their symptoms over 28 days in a diary.

If eligible to take participate in the study, people were taken through what the study was and what would happen to their data and samples. If they agreed to take part, they each signed a consent form and parents or guardian gave permission for over 5 year olds but under 18s to take part. The study looked at what proportion of infections that are symptom-free, what are the risk factors of COVID-19 transmission within household and whether early immune responses could predict if a recently-exposed person (contact) will have a symptom-free infection or instead develop symptomatic or severe illness..

DGP Pathoseal 95 biohazard bag numbered 18463552 containing 2 Nasosorption FX.i nasal sampling device, reference NSFL-FXI-11, lot number HMD-20-15396, date of manufacture 2020-07, expiry date 2022-07, manufactured by Hunt Developments (UK) Ltd, and rectangle of absorbent material used for sample collection from people enrolled on the Integrated Network for Surveillance, Trials and Investigation of COVID-19 Transmission (INSTINCT) study, 2020

In the INSTINCT study, household contacts living with people with a recent COVID-19 infection were enrolled at home by research nurses (day 0) and visited again on days 7, 14 and 27. Nasal samples were taken to test for people’s immune responses and then be able to compare it to those in people’s blood samples. Stool and swabs to test for COVID-19 are also taken. Sampling over time helps identify virus changes and mutations and identify if there are any links between specific strains of virus and disease outcome. Participants also tracked their symptoms over 28 days in a diary.

If eligible to take participate in the study, people were taken through what the study was and what would happen to their data and samples. If they agreed to take part, they each signed a consent form and parents or guardian gave permission for over 5 year olds but under 18s to take part. The study looked at what proportion of infections that are symptom-free, what are the risk factors of COVID-19 transmission within household and whether early immune responses could predict if a recently-exposed person (contact) will have a symptom-free infection or instead develop symptomatic or severe illness.

DGP Pathoseal 95 biohazard bag numbered 18463536 containing Sterilin 20ml conical tube with screw cap, flat wooden stick, pair of nitrile gloves, instruction titled ‘How to Scoop the Poop!!’, and rectangle of absorbent material, used for sample collection from people enrolled on the Integrated Network for Surveillance, Trials and Investigation of COVID-19 Transmission (INSTINCT) study, 2020

In the INSTINCT study, household contacts living with people with a recent COVID-19 infection were enrolled at home by research nurses (day 0) and visited again on days 7, 14 and 27. Stool samples were taken to see if the virus was present in and if so for how long and if COVID-19 could be transmitted this way. Blood and nasal swabs were taken. PCR tests were also carried out on combined nose and throat swabs. Sampling over time helps identify virus changes and mutations and identify if there are any links between specific strains of virus and disease outcome. Participants also tracked their symptoms over 28 days in a diary.

If eligible to take participate in the study, people were taken through what the study was and what would happen to their data and samples. If they agreed to take part, they each signed a consent form and parents or guardian gave permission for over 5 year olds but under 18s to take part. The study looked at what proportion of infections that are symptom-free, what are the risk factors of COVID-19 transmission within household and whether early immune responses could predict if a recently-exposed person (contact) will have a symptom-free infection or instead develop symptomatic or severe illness.

11 page Participant Information Sheet – Adults Cohort 1 Contacts and Indexes – Remote visits, version 1 dated 30 September 2020, for people invited to take part in the Integrated Network for Surveillance, Trials and Investigation of COVID-19 Transmission (INSTINCT) study, 2020

In the INSTINCT study, household contacts living with people with a recent COVID-19 infection were enrolled at home by research nurses (day 0) and visited again on days 7, 14 and 27. Blood, nasal and stool samples were taken to help understand virus changes over time, transmission and identify if there are any links between specific strains of virus and disease outcome. People’s immune responses were also tested from samples to understand which part of their system is responding to COVID-19.

If eligible to take participate in the study, people were taken through what the study was and what would happen to their data and samples. If they agreed to take part, they each signed a consent form and parents or guardian gave permission for over 5 year olds but under 18s to take part. The study looked at what proportion of infections that are symptom-free, what are the risk factors of COVID-19 transmission within household and whether early immune responses could predict if a recently-exposed person (contact) will have a symptom-free infection or instead develop symptomatic or severe illness.

3 page blank Participant Consent Form – Adults Cohort 1 – Remote visit, version 1 dated 30 September 2020, for people participating in the Integrated Network for Surveillance, Trials and Investigation of COVID-19 Transmission (INSTINCT) study, 2020

In the INSTINCT study, household contacts living with people with a recent COVID-19 infection were enrolled at home by research nurses (day 0) and visited again on days 7, 14 and 27. Blood, nasal and stool samples were taken to help understand virus changes over time, transmission and identify if there are any links between specific strains of virus and disease outcome. People’s immune responses were also tested from samples to understand which part of their system is responding to COVID-19.

If eligible to take participate in the study, people were taken through what the study was and what would happen to their data and samples. If they agreed to take part, they each signed a consent form and parents or guardian gave permission for over 5 year olds but under 18s to take part. The study looked at what proportion of infections that are symptom-free, what are the risk factors of COVID-19 transmission within household and whether early immune responses could predict if a recently-exposed person (contact) will have a symptom-free infection or instead develop symptomatic or severe illness.

11 page blank Daily Symptom and Temperature Tracker - Days 0 to 8, version 1 dated 30 July 2020, for people participating in the Integrated Network for Surveillance, Trials and Investigation of COVID-19 Transmission (INSTINCT) study, 2020

In the INSTINCT study, household contacts living with people with a recent COVID-19 infection were enrolled at home by research nurses (day 0) and visited again on days 7, 14 and 27. Blood, nasal and stool samples were taken to help understand virus changes over time, transmission and identify if there are any links between specific strains of virus and disease outcome. People’s immune responses were also tested from samples to understand which part of their system is responding to COVID-19.

If eligible to take participate in the study, people were taken through what the study was and what would happen to their data and samples. If they agreed to take part, they each signed a consent form and parents or guardian gave permission for over 5 year olds but under 18s to take part. The study looked at what proportion of infections that are symptom-free, what are the risk factors of COVID-19 transmission within household and whether early immune responses could predict if a recently-exposed person (contact) will have a symptom-free infection or instead develop symptomatic or severe illness.

13 page Participant Information Sheet – Adults Cohort 2 and 3, version 2 dated 30 July 2020, for people invited to take part in the Integrated Network for Surveillance, Trials and Investigation of COVID-19 Transmission (INSTINCT) study, 2020

In the INSTINCT study, household contacts living with people with a recent COVID-19 infection were enrolled at home by research nurses (day 0) and visited again on days 7, 14 and 27. Blood, nasal and stool samples were taken to help understand virus changes over time, transmission and identify if there are any links between specific strains of virus and disease outcome. People’s immune responses were also tested from samples to understand which part of their system is responding to COVID-19.

If eligible to take participate in the study, people were taken through what the study was and what would happen to their data and samples. If they agreed to take part, they each signed a consent form and parents or guardian gave permission for over 5 year olds but under 18s to take part. The study looked at what proportion of infections that are symptom-free, what are the risk factors of COVID-19 transmission within household and whether early immune responses could predict if a recently-exposed person (contact) will have a symptom-free infection or instead develop symptomatic or severe illness.

3 page blank Participant Consent Form – Adults Cohort 2 and 3, version 1 dated 30 July 2020, for participating in the Integrated Network for Surveillance, Trials and Investigation of COVID-19 Transmission (INSTINCT) study, 2020

In the INSTINCT study, household contacts living with people with a recent COVID-19 infection were enrolled at home by research nurses (day 0) and visited again on days 7, 14 and 27. Blood, nasal and stool samples were taken to help understand virus changes over time, transmission and identify if there are any links between specific strains of virus and disease outcome. People’s immune responses were also tested from samples to understand which part of their system is responding to COVID-19.

If eligible to take participate in the study, people were taken through what the study was and what would happen to their data and samples. If they agreed to take part, they each signed a consent form and parents or guardian gave permission for over 5 year olds but under 18s to take part. The study looked at what proportion of infections that are symptom-free, what are the risk factors of COVID-19 transmission within household and whether early immune responses could predict if a recently-exposed person (contact) will have a symptom-free infection or instead develop symptomatic or severe illness.

3 page blank Participant Consent Form – Adults Cohort 2 and 3, version 1 dated 30 July 2020, for participating in the Integrated Network for Surveillance, Trials and Investigation of COVID-19 Transmission (INSTINCT) study, 2020

In the INSTINCT study, household contacts living with people with a recent COVID-19 infection were enrolled at home by research nurses (day 0) and visited again on days 7, 14 and 27. Blood, nasal and stool samples were taken to help understand virus changes over time, transmission and identify if there are any links between specific strains of virus and disease outcome. People’s immune responses were also tested from samples to understand which part of their system is responding to COVID-19.

If eligible to take participate in the study, people were taken through what the study was and what would happen to their data and samples. If they agreed to take part, they each signed a consent form and parents or guardian gave permission for over 5 year olds but under 18s to take part. The study looked at what proportion of infections that are symptom-free, what are the risk factors of COVID-19 transmission within household and whether early immune responses could predict if a recently-exposed person (contact) will have a symptom-free infection or instead develop symptomatic or severe illness.

12 page blank Case Record Form – Baseline Visit, version 2 dated 30 July 2020, for people invited to take part in the Integrated Network for Surveillance, Trials and Investigation of COVID-19 Transmission (INSTINCT) study, 2020

In the INSTINCT study, household contacts living with people with a recent COVID-19 infection were enrolled at home by research nurses (day 0) and visited again on days 7, 14 and 27. Blood, nasal and stool samples were taken to help understand virus changes over time, transmission and identify if there are any links between specific strains of virus and disease outcome. People’s immune responses were also tested from samples to understand which part of their system is responding to COVID-19.

If eligible to take participate in the study, people were taken through what the study was and what would happen to their data and samples. If they agreed to take part, they each signed a consent form and parents or guardian gave permission for over 5 year olds but under 18s to take part. The study looked at what proportion of infections that are symptom-free, what are the risk factors of COVID-19 transmission within household and whether early immune responses could predict if a recently-exposed person (contact) will have a symptom-free infection or instead develop symptomatic or severe illness.

Blank Sample Tracking Form, version 1.1 dated 10 June 2020 , for people participating in Integrated Network for Surveillance, Trials and Investigation of COVID-19 Transmission (INSTINCT) study, 2020

In the INSTINCT study, household contacts living with people with a recent COVID-19 infection were enrolled at home by research nurses (day 0) and visited again on days 7, 14 and 27. Blood, nasal and stool samples were taken to help understand virus changes over time, transmission and identify if there are any links between specific strains of virus and disease outcome. People’s immune responses were also tested from samples to understand which part of their system is responding to COVID-19.

If eligible to take participate in the study, people were taken through what the study was and what would happen to their data and samples. If they agreed to take part, they each signed a consent form and parents or guardian gave permission for over 5 year olds but under 18s to take part. The study looked at what proportion of infections that are symptom-free, what are the risk factors of COVID-19 transmission within household and whether early immune responses could predict if a recently-exposed person (contact) will have a symptom-free infection or instead develop symptomatic or severe illness.

11 page blank Daily Symptom and Temperature Tracker - Days 0 to 8, version 1 dated 30 July 2020, for people participating in the Integrated Network for Surveillance, Trials and Investigation of COVID-19 Transmission (INSTINCT) study, 2020

In the INSTINCT study, household contacts living with people with a recent COVID-19 infection were enrolled at home by research nurses (day 0) and visited again on days 7, 14 and 27. Blood, nasal and stool samples were taken to help understand virus changes over time, transmission and identify if there are any links between specific strains of virus and disease outcome. People’s immune responses were also tested from samples to understand which part of their system is responding to COVID-19.

If eligible to take participate in the study, people were taken through what the study was and what would happen to their data and samples. If they agreed to take part, they each signed a consent form and parents or guardian gave permission for over 5 year olds but under 18s to take part. The study looked at what proportion of infections that are symptom-free, what are the risk factors of COVID-19 transmission within household and whether early immune responses could predict if a recently-exposed person (contact) will have a symptom-free infection or instead develop symptomatic or severe illness.

11 page blank Daily Symptom and Temperature Tracker - Days 9 to 28, version 1 dated 30 July 2020, for people invited to take part in the Integrated Network for Surveillance, Trials and Investigation of COVID-19 Transmission (INSTINCT) study, 2020

In the INSTINCT study, household contacts living with people with a recent COVID-19 infection were enrolled at home by research nurses (day 0) and visited again on days 7, 14 and 27. Blood, nasal and stool samples were taken to help understand virus changes over time, transmission and identify if there are any links between specific strains of virus and disease outcome. People’s immune responses were also tested from samples to understand which part of their system is responding to COVID-19.

If eligible to take participate in the study, people were taken through what the study was and what would happen to their data and samples. If they agreed to take part, they each signed a consent form and parents or guardian gave permission for over 5 year olds but under 18s to take part. The study looked at what proportion of infections that are symptom-free, what are the risk factors of COVID-19 transmission within household and whether early immune responses could predict if a recently-exposed person (contact) will have a symptom-free infection or instead develop symptomatic or severe illness.

3 page Participant Information Sheet – Cohort 2 and 3: Young person aged 11-15, version 2 dated 30 July 2020, for young people invited to take part in the Integrated Network for Surveillance, Trials and Investigation of COVID-19 Transmission (INSTINCT) study, 2020

In the INSTINCT study, household contacts living with people with a recent COVID-19 infection were enrolled at home by research nurses (day 0) and visited again on days 7, 14 and 27. Blood, nasal and stool samples were taken to help understand virus changes over time, transmission and identify if there are any links between specific strains of virus and disease outcome. People’s immune responses were also tested from samples to understand which part of their system is responding to COVID-19.

If eligible to take participate in the study, people were taken through what the study was and what would happen to their data and samples. If they agreed to take part, they each signed a consent form and parents or guardian gave permission for over 5 year olds but under 18s to take part. The study looked at what proportion of infections that are symptom-free, what are the risk factors of COVID-19 transmission within household and whether early immune responses could predict if a recently-exposed person (contact) will have a symptom-free infection or instead develop symptomatic or severe illness.

Blank Participant Assent Form – child aged 5-10 and young person aged 11-15, version 2.0 dated 30 July 2020, for young people invited to take part in the Integrated Network for Surveillance, Trials and Investigation of COVID-19 Transmission (INSTINCT) study, 2020

In the INSTINCT study, household contacts living with people with a recent COVID-19 infection were enrolled at home by research nurses (day 0) and visited again on days 7, 14 and 27. Blood, nasal and stool samples were taken to help understand virus changes over time, transmission and identify if there are any links between specific strains of virus and disease outcome. People’s immune responses were also tested from samples to understand which part of their system is responding to COVID-19.

If eligible to take participate in the study, people were taken through what the study was and what would happen to their data and samples. If they agreed to take part, they each signed a consent form and parents or guardian gave permission for over 5 year olds but under 18s to take part. The study looked at what proportion of infections that are symptom-free, what are the risk factors of COVID-19 transmission within household and whether early immune responses could predict if a recently-exposed person (contact) will have a symptom-free infection or instead develop symptomatic or severe illness.

Blank Participant Assent Form – child aged 5-10 and young person aged 11-15, version 2.0 dated 30 July 2020, for young people invited to take part in the Integrated Network for Surveillance, Trials and Investigation of COVID-19 Transmission (INSTINCT) study, 2020

In the INSTINCT study, household contacts living with people with a recent COVID-19 infection were enrolled at home by research nurses (day 0) and visited again on days 7, 14 and 27. Blood, nasal and stool samples were taken to help understand virus changes over time, transmission and identify if there are any links between specific strains of virus and disease outcome. People’s immune responses were also tested from samples to understand which part of their system is responding to COVID-19.

If eligible to take participate in the study, people were taken through what the study was and what would happen to their data and samples. If they agreed to take part, they each signed a consent form and parents or guardian gave permission for over 5 year olds but under 18s to take part. The study looked at what proportion of infections that are symptom-free, what are the risk factors of COVID-19 transmission within household and whether early immune responses could predict if a recently-exposed person (contact) will have a symptom-free infection or instead develop symptomatic or severe illness.

11 page blank Daily Symptom and Temperature Tracker - Days 0 to 8, version 2 dated 30 July 2020, for people participating in the Integrated Network for Surveillance, Trials and Investigation of COVID-19 Transmission (INSTINCT) study, 2020

In the INSTINCT study, household contacts living with people with a recent COVID-19 infection were enrolled at home by research nurses (day 0) and visited again on days 7, 14 and 27. Blood, nasal and stool samples were taken to help understand virus changes over time, transmission and identify if there are any links between specific strains of virus and disease outcome. People’s immune responses were also tested from samples to understand which part of their system is responding to COVID-19.

If eligible to take participate in the study, people were taken through what the study was and what would happen to their data and samples. If they agreed to take part, they each signed a consent form and parents or guardian gave permission for over 5 year olds but under 18s to take part. The study looked at what proportion of infections that are symptom-free, what are the risk factors of COVID-19 transmission within household and whether early immune responses could predict if a recently-exposed person (contact) will have a symptom-free infection or instead develop symptomatic or severe illness.

11 page blank Daily Symptom and Temperature Tracker - Days 9 to 28, version 2 dated 30 July 2020, for people invited to take part in the Integrated Network for Surveillance, Trials and Investigation of COVID-19 Transmission (INSTINCT) study, 2020

In the INSTINCT study, household contacts living with people with a recent COVID-19 infection were enrolled at home by research nurses (day 0) and visited again on days 7, 14 and 27. Blood, nasal and stool samples were taken to help understand virus changes over time, transmission and identify if there are any links between specific strains of virus and disease outcome. People’s immune responses were also tested from samples to understand which part of their system is responding to COVID-19.

If eligible to take participate in the study, people were taken through what the study was and what would happen to their data and samples. If they agreed to take part, they each signed a consent form and parents or guardian gave permission for over 5 year olds but under 18s to take part. The study looked at what proportion of infections that are symptom-free, what are the risk factors of COVID-19 transmission within household and whether early immune responses could predict if a recently-exposed person (contact) will have a symptom-free infection or instead develop symptomatic or severe illness.

Blank Sample Tracking Form, version 1.1 dated 10 June 2020, for people participating in Integrated Network for Surveillance, Trials and Investigation of COVID-19 Transmission (INSTINCT) study, 2020

In the INSTINCT study, household contacts living with people with a recent COVID-19 infection were enrolled at home by research nurses (day 0) and visited again on days 7, 14 and 27. Blood, nasal and stool samples were taken to help understand virus changes over time, transmission and identify if there are any links between specific strains of virus and disease outcome. People’s immune responses were also tested from samples to understand which part of their system is responding to COVID-19.

If eligible to take participate in the study, people were taken through what the study was and what would happen to their data and samples. If they agreed to take part, they each signed a consent form and parents or guardian gave permission for over 5 year olds but under 18s to take part. The study looked at what proportion of infections that are symptom-free, what are the risk factors of COVID-19 transmission within household and whether early immune responses could predict if a recently-exposed person (contact) will have a symptom-free infection or instead develop symptomatic or severe illness.

12 page blank Case Record Form – Baseline Visit, version 2 dated 30 July 2020, for people invited to take part in the Integrated Network for Surveillance, Trials and Investigation of COVID-19 Transmission (INSTINCT) study, 2020

In the INSTINCT study, household contacts living with people with a recent COVID-19 infection were enrolled at home by research nurses (day 0) and visited again on days 7, 14 and 27. Blood, nasal and stool samples were taken to help understand virus changes over time, transmission and identify if there are any links between specific strains of virus and disease outcome. People’s immune responses were also tested from samples to understand which part of their system is responding to COVID-19.

If eligible to take participate in the study, people were taken through what the study was and what would happen to their data and samples. If they agreed to take part, they each signed a consent form and parents or guardian gave permission for over 5 year olds but under 18s to take part. The study looked at what proportion of infections that are symptom-free, what are the risk factors of COVID-19 transmission within household and whether early immune responses could predict if a recently-exposed person (contact) will have a symptom-free infection or instead develop symptomatic or severe illness.

3 page blank Parent/Legal guardian Consent Form – for children aged 5-15, version 2 dated 30 July 2020, for people participating in the Integrated Network for Surveillance, Trials and Investigation of COVID-19 Transmission (INSTINCT) study, 2020

In the INSTINCT study, household contacts living with people with a recent COVID-19 infection were enrolled at home by research nurses (day 0) and visited again on days 7, 14 and 27. Blood, nasal and stool samples were taken to help understand virus changes over time, transmission and identify if there are any links between specific strains of virus and disease outcome. People’s immune responses were also tested from samples to understand which part of their system is responding to COVID-19.

If eligible to take participate in the study, people were taken through what the study was and what would happen to their data and samples. If they agreed to take part, they each signed a consent form and parents or guardian gave permission for over 5 year olds but under 18s to take part. The study looked at what proportion of infections that are symptom-free, what are the risk factors of COVID-19 transmission within household and whether early immune responses could predict if a recently-exposed person (contact) will have a symptom-free infection or instead develop symptomatic or severe illness.

Eligibity form for Integrated Network for Surveillance, Trials and Investigation of COVID-19 Transmission (INSTINCT) study, 2020

In the INSTINCT study, household contacts living with people with a recent COVID-19 infection were enrolled at home by research nurses (day 0) and visited again on days 7, 14 and 27. Blood, nasal and stool samples were taken to help understand virus changes over time, transmission and identify if there are any links between specific strains of virus and disease outcome. People’s immune responses were also tested from samples to understand which part of their system is responding to COVID-19.

If eligible to take participate in the study, people were taken through what the study was and what would happen to their data and samples. If they agreed to take part, they each signed a consent form and parents or guardian gave permission for over 5 year olds but under 18s to take part. The study looked at what proportion of infections that are symptom-free, what are the risk factors of COVID-19 transmission within household and whether early immune responses could predict if a recently-exposed person (contact) will have a symptom-free infection or instead develop symptomatic or severe illness.

DGP Pathoseal 95 biohazard bag A4 numbered 21044322 part of Integrated Network for Surveillance, Trials and Investigation of COVID-19 Transmission (INSTINCT) study undertaken at Imperial College's NIHR Health Protection Research Unit (HPRU) at St Mary's Hospital, London, UK, 2020

In the INSTINCT study, household contacts living with people with a recent COVID-19 infection were enrolled at home by research nurses (day 0) and visited again on days 7, 14 and 27. Blood, nasal and stool samples were taken to help understand virus changes over time, transmission and identify if there are any links between specific strains of virus and disease outcome. People’s immune responses were also tested from samples to understand which part of their system is responding to COVID-19.

If eligible to take participate in the study, people were taken through what the study was and what would happen to their data and samples. If they agreed to take part, they each signed a consent form and parents or guardian gave permission for over 5 year olds but under 18s to take part. The study looked at what proportion of infections that are symptom-free, what are the risk factors of COVID-19 transmission within household and whether early immune responses could predict if a recently-exposed person (contact) will have a symptom-free infection or instead develop symptomatic or severe illness.