Sherlock was a painter and engraver who studied at the Slade School, Westminster, the Royal College of Art and Paris. She was associated with the Camden Town Group artists and studied with Walter Sickert and Harold Gilman. She exhibited in group shows at the Royal Academy, the New English Art Club, the Carnegie Institute, Pittsburgh, the Society of Graphic Art, the International Society of Sculptors, Painters, and Gravers, the Royal Society of British Artists, and the Chicago Society of Etchers.